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Neil R. Thomas

Professor of Medicinal and Biological Chemistry, Faculty of Science

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Biography

Professor Thomas began his academic career with a 1st Class B.Sc. (Hons) in Chemistry from the University of Southampton in 1987. Remaining there, under the supervision of Professor D. Gani, he obtained his Ph.D. in 1990 working on the elucidation of the mechanism of the pyridoxal phosphate (vitamin B6) dependent enzyme serine hydroxymethyltransferase and 3-methylaspartase. He then worked for the following two years as a NATO/SERC Fellow with Prof. S. J. Benkovic at the Pennsylvania State University, USA. on both the generation and characterisation of catalytic antibodies and the reaction catalysed by dihydrofolate reductase. He returned to the UK in 1992 as a Royal Society University Research Fellow and lecturer at the University of Bath. In 1995, he moved to the School of Chemistry at the 糖心原创, initially as a Royal Society University Research Fellow and lecturer and then in 2003 as a Senior Lecturer/Associate Professor before becoming Professor of Medicinal & Biological Chemistry in January 2008. His current research interests are in the identification of inhibitors of enzymes essential to Mycobacterium cell wall biosynthesis; synthesis of mechanistic probes based on Coenzyme A, S-adenosylmethione, ATP and biotin; use of enzymes in unusual reaction media (fluorous biphasic systems; supercritical fluids); development of enzyme-based antimicrobial therapies; development of enzyme-activated magnetic resonance imaging (MRI) agents; development of in vivo probes based on quantum dots and protein capsids; healthcare applications of self-assembling proteins including apoferritin and spider silk. He is currently the Biological Chemistry Theme (Division) head. He has served as a pool and core member of BBSRC Committee C (2010-2014) and the BBSRC TRDF committee, and on the RSC Chemical Biology and Biological Chemistry Interest Group (2008-2016)

He has been Director of Teaching for the School of chemistry and developed the Medicinal and Biological Chemistry family of degree courses in 2005, as well as the assessed year in Industry courses with other colleagues.

Since 2018 he has been a Deputy Director of the 糖心原创 Biodiscovery Institute which accommodates more than 80 principal academic investigators and 800+ researchers from the Schools of Chemistry, Life Sciences, Medicine, Pharmacy and Veterinary Science.

Expertise Summary

Mechanistic Enzymology; Protein Engineering; Bio-conjugate Chemistry; Enzyme Evolution; Coenzyme Chemistry; Enzyme Inhibitor design; Medicinal Chemistry; Imaging Probe creation (MRI, fluorescence, chemiluminescence)

Teaching Summary

My teaching includes the CHEM2011 Medicinal Chemistry and Molecular and Microbiology module as well as the CHEM4026 Bioorganic Mechanisms and Nucleic Acids module for undergraduates and lectures on… read more

Research Summary

Bioorganic Chemistry; Chemical Biology; Biological Chemistry; Enzyme Mechanism; Enzyme Inhibitor; Biomimetic Catalysts; Catalytic Antibodies; Phage Display; Serine Hydroxymethyltransferase; Dioxetane… read more

Selected Publications

  • KING, TOBY E., HUMPHREY, JAMES R., LAUGHTON, CHARLES A., THOMAS, NEIL R. and HIRST, JONATHAN D., 2024. Journal of Chemical Information and Modeling. 64(1), 265-275
  • ABUZAID, HANEEN, ABDELRAZIG, SALAH, FERREIRA, LENNY, COLLINS, HILARY M., KIM, DONG-HYUN, LIM, KUAN-HON, KAM, TOH-SEOK, THOMAS, NEIL R., TURYANSKA, LYUDMILA and BRADSHAW, TRACEY D., 2024. ACS Omega. 9(1), 2012-2012
  • ABUZAID, H., ABDELRAZIG, S., FERREIRA, L., COLLINS, H. M., KIM, D.-H., LIM, K. H., KAM, T.-S., TURYANSKA, L. and BRADSHAW, T. D., 2022. ACS Omega.
  • AL-ANI, ALI W., ZAMBERLAN, FRANCESCO, FERREIRA, LENNY, BRADSHAW, TRACEY D., THOMAS, NEIL R. and TURYANSKA, LYUDMILA, 2021. NANO EXPRESS. 2(4),

My teaching includes the CHEM2011 Medicinal Chemistry and Molecular and Microbiology module as well as the CHEM4026 Bioorganic Mechanisms and Nucleic Acids module for undergraduates and lectures on Chemical modification of proteins and bioconjugation.

Current Research

Bioorganic Chemistry; Chemical Biology; Biological Chemistry; Enzyme Mechanism; Enzyme Inhibitor; Biomimetic Catalysts; Catalytic Antibodies; Phage Display; Serine Hydroxymethyltransferase; Dioxetane chemiluminescence; galactopyranose mutase; glycosidase; biomaterials, quantum dots; spider silk; directed evolution; protein nano cages; drug delivery; affibodies; biocatalysis; antimicrobial enzymes.

  • KING, TOBY E., HUMPHREY, JAMES R., LAUGHTON, CHARLES A., THOMAS, NEIL R. and HIRST, JONATHAN D., 2024. Journal of Chemical Information and Modeling. 64(1), 265-275
  • ABUZAID, HANEEN, ABDELRAZIG, SALAH, FERREIRA, LENNY, COLLINS, HILARY M., KIM, DONG-HYUN, LIM, KUAN-HON, KAM, TOH-SEOK, THOMAS, NEIL R., TURYANSKA, LYUDMILA and BRADSHAW, TRACEY D., 2024. ACS Omega. 9(1), 2012-2012
  • ABUZAID, H., ABDELRAZIG, S., FERREIRA, L., COLLINS, H. M., KIM, D.-H., LIM, K. H., KAM, T.-S., TURYANSKA, L. and BRADSHAW, T. D., 2022. ACS Omega.
  • SAFO, L., ABDELRAZIG, S., GROSSE-HONEBRINK, A., MILLAT, T., HENSTRA, A. M., NORMAN, RUPERT, THOMAS, NEIL R., WINZER, KLAUS, MINTON, NIGEL, KIM, DONG-HYUN and BARRETT, DAVID, 2021. ACS Omega. 6(21), 13518鈥�13526
  • CHETTY, S., ARMSTRONG, T, DREWE, W.C., DREWE, W.C., DE MATTEIS, C.I., EVANGELOPOULOS, D., BHAKTA, S. and THOMAS, N.R., 2021. Pharmaceuticals. 14(4), 361
  • AL-ANI, ALI W., ZAMBERLAN, FRANCESCO, FERREIRA, LENNY, BRADSHAW, TRACEY D., THOMAS, NEIL R. and TURYANSKA, LYUDMILA, 2021. NANO EXPRESS. 2(4),
  • BOUZINAB K, SUMMERS HS, STEVENS MFG, MOODY CJ, THOMAS NR, GERSHKOVICH P, WESTON N, ASHFORD MB, BRADSHAW TD and TURYANSKA L, 2020. ACS applied materials & interfaces. 12(11), 12609-12617
  • ARMSTRONG, TOM, LAMONT, MALCOLM, LANNE, ALICE, ALDERWICK, LUKE J and THOMAS, NEIL R, 2020. Bioorganic & medicinal chemistry. 28(22), 115744
  • HARVEY, DAVID, BRAY, GEMMA, ZAMBERLAN, FRANCESCO, AMER, MAHETAB, GOODACRE, SARA L. and THOMAS, NEIL R., 2020. MACROMOLECULAR BIOSCIENCE.
  • FAAS H, KRUPA J, TAYLOR A, ZAMBERLAN F, PHILP C, WILLIAMS S, JOHNSON S, PAVLOVSKAYA G, THOMAS NR and MEERSMANN T, 2019. Contrast Media & Molecular Imaging. 2019, 4826520
  • AL-ANI, ALI W, ZHANG, LEI, FERREIRA, LENNY, TURYANSKA, LYUDMILA, BRADSHAW, TRACEY D and THOMAS, NEIL R, 2019. Nanomedicine : nanotechnology, biology, and medicine. 20, 102005
  • ZHANG, CHENGXI, TURYANSKA, LYUDMILA, CAO, HAICHENG, ZHAO, LIXIA, FAY, MICHAEL W, TEMPERTON, ROBERT, O'SHEA, JAMES, THOMAS, NEIL R, WANG, KAIYOU, LUAN, WEILING and PATANE, AMALIA, 2019. Nanoscale. 11, 13450-13457
  • LIU, ZHIMIN, TURYANSKA, LYUDMILA, ZAMBERLAN, FRANCESCO, PACIFICO, SALVATORE, BRADSHAW, TRACEY D, MORO, FABRIZIO, FAY, MICHAEL W, WILLIAMS, HUW and THOMAS, NEIL R, 2019. Nanotechnology. 30, 505102
  • KAOUTHAR BOUZINAB, HELEN SUMMERS, JIHONG ZHANG, MALCOLM F. G. STEVENS, CHRISTOPHER J. MOODY, LYUDMILA TURYANSKA, NEIL R. THOMAS, PAVEL GERSHKOVICH, MARIANNE B. ASHFORD, EMILY VITTERSO, LISA C. D. STORER, RICHARD GRUNDY and TRACEY D. BRADSHAW, 2019. Cancer Drug Resistance. 2,
  • BOUZINAB, KAOUTHAR, THOMAS, NEIL R., TURYANSKA, LYUDMILA, GERSHKOVICH, PAVEL, WESTON, NICOLA, ASHFORD, MARIANNE B. and BRADSHAW, TRACEY D., 2019. NEURO-ONCOLOGY. 21, 4-4
  • A F BREEN, D SCURR, M L CASSIOLI, G WELLS, N R THOMAS, L TURYANSKA and T D BRADSHAW, 2019. International Journal of Nanomedicine. 14, 9525-9534
  • ZAMBERLAN, F., TURYANSKA, L., PATANE, A., LIU, Z., WILLIAMS, H. E. L., FAY, M. W., CLARKE, P. A., IMAMURA, Y., JIN, T., BRADSHAW, T. D., THOMAS, N. R. and GRABOWSKA, A. M., 2018. Journal of Materials Chemistry B. 6(4), 550-555
  • STRICKLAND M, TUDORICA V, 艠EZ脕膶 M, THOMAS NR and GOODACRE SL, 2018. Heredity. 120, 574鈥�580
  • HARVEY, DAVID, BARDELANG, PHILIP, GOODACRE, SARA L., COCKAYNE, ALAN and THOMAS, NEIL R., 2017. ADVANCED MATERIALS. 29(10),
  • TURYANSKA, LYUDMILA, MORO, FABRIZIO, PATANE, AMALIA, BARR, JAMES, KOCKENBERGER, WALTER, TAYLOR, ALEXANDER, FAAS, HENRYK M., FOWLER, MAXINE, WIGMORE, PETER, TRUEMAN, REBECCA C., WILLIAMS, HUW E. L. and THOMAS, NEIL R., 2016. J. Mater. Chem. B. 4, 6797-6802
  • TAYLOR AJ, GRANWEHR J, LESBATS C, KRUPA JL, SIX JS, PAVLOVSKAYA GE, THOMAS NR, AUER DP, MEERSMANN T and FAAS HM, 2016. PloS one. 11(10), e0163704
  • ZAMBERLAN, FRANCESCO, LESBATS, CLEMENTINE, ROGERS, NICOLA J., KRUPA, JAMES L., PAVLOVSKAYA, GALINA E., THOMAS, NEIL R., FAAS, HENRYK M. and MEERSMANN, THOMAS, 2015. CHEMPHYSCHEM. 16(11), 2294-2298
  • TURYANSKA, LYUDMILA, MAKAROVSKY, OLEG, SVATEK, SIMON A., BETON, PETER H., MELLOR, CHRISTOPHER J., PATANE, AMALIA, EAVES, LAURENCE, THOMAS, NEIL R., FAY, MICHAEL W., MARSDEN, ALEXANDER J. and WILSON, NEIL R., 2015. ADVANCED ELECTRONIC MATERIALS. 1(7),
  • HUMPHREYS, CHRISTOPHER M., MCLEAN, SAMANTHA, SCHATSCHNEIDER, SARAH, MILLAT, THOMAS, HENSTRA, ANNE M., ANNAN, FLORENCE J., BREITKOPF, RONJA, PANDER, BART, PIATEK, PAWEL, ROWE, PETER, WICHLACZ, ALEXANDER T., WOODS, CRAIG, NORMAN, RUPERT, BLOM, JOCHEN, GOESMAN, ALEXANDER, HODGMAN, CHARLIE, BARRETT, DAVID, THOMAS, NEIL R., WINZER, KLAUS and MINTON, NIGEL P., 2015. BMC GENOMICS. 16,
  • KURUPPU, ANCHALA I., ZHANG, LEI, COLLINS, HILARY, TURYANSKA, LYUDMILA, THOMAS, NEIL R. and BRADSHAW, TRACEY D., 2015. ADVANCED HEALTHCARE MATERIALS. 4(18), 2816-2821
  • SABALA, IZABELA, JAGIELSKA, ELZBIETA, BARDELANG, PHILIP T., CZAPINSKA, HONORATA, DAHMS, SVEN O., SHARPE, JASON A., JAMES, RICHARD, THAN, MANUEL E., THOMAS, NEIL R. and BOCHTLER, MATTHIAS, 2014. FEBS JOURNAL. 281(18), 4112-4122
  • HARLAND, MICHAEL D., MAY, TERRY J. and THOMAS, NEIL R., 2013. Synthesis of a novel inhibitor of cell wall biosynthesis in Mycobacterium tuberculosis ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 245,
  • TURPIN ER, FANG H, THOMAS NR and HIRST JD, 2013. Biochemistry. 52(27), 4723-33
  • BRADSHAW, TRACEY D., JUNOR, MARC, PATANE, AMALIA, CLARKE, PHIL, THOMAS, NEIL R., LI, MEI, MANN, STEPHEN and TURYANSKA, LYUDMILA, 2013. JOURNAL OF MATERIALS CHEMISTRY B. 1(45), 6254-6260
  • PARTHA SK, SADEGHI-KHOMAMI, A, CREN, S, ROBINSON RI, WOODWARD, S, SLOWSKI, K, BERAST, L, ZHENG, B, THOMAS, NR and SANDERS, DAR, 2012. Molecular Informatics. 30(10), 873-883
  • TURYANSKA, L, BRADSHAW, TD, LI, M, BARDELANG, P, DREWE, WC, FAY, MW, MANN, S, PATANE, A and THOMAS, NR, 2012. Journal Of Materials Chemistry. 22(2), 660-665
  • SADEGHI-KHOMAMI, ALI, FORCADA, TATIANA J, WILSON, CLAIRE, SANDERS, DAVID A R and THOMAS, NEIL R, 2010. The UDP-Galp mutase catalyzed isomerization: synthesis and evaluation of 1,4-anhydro-beta-D-galactopyranose and its [2.2.2] methylene homologue. Organic & biomolecular chemistry. 8(7), 1596-602
  • ROTH, S. and THOMAS, N.R., 2010. Synlett. 607-609
  • BENAISSI, K., POLIAKOFF, M. and THOMAS, N.R., 2010. Green Chemistry. 12(1), 54-59
  • THOMAS, N. R., 2010. Cellular and Biomolecular Recognition: Synthetic and non-Biological Molecules. Edited by Raz Jelinek.. VOL 11(NUMBER 3), 435-435
  • ROTH, S, DREWE, WC and THOMAS, NR, 2010. Nature Protocols. 5(12), 1967-1973
  • PARTHA, S.K., SADEGHI-KHOMAMI, A., SLOWSKI, K., KOTAKE, T., THOMAS, N.R., JAKEMAN, D.L. and SANDERS, D.A.R., 2010. Journal of Molecular Biology. 403(4), 578-590
  • KHIM, L, HAN, JA, WILLETTS, L, BRADY, K, GILLECE, P, RACHED, O, THOMAS, NR and STYLIANOU, E, 2010. Chembiochem. 11(15), 2100-2103
  • TURYANSKA, L., ELFURAWI, U., LI, M., FAY, M. W., THOMAS, N. R., MANN, S., BLOKLAND, J. H., CHRISTIANEN, P. C. M. and PATANE, A., 2009. Tailoring the physical properties of thiol-capped PbS quantum dots by thermal annealing Nanotechnology. 20(31), 315604 (5 pages)
  • TOWNSEND, A.P., ROTH, S., WILLIAMS, H.E.L., STYLIANOU, E. and THOMAS, N.R., 2009. Organic Letters. 11(14), 2976-2979
  • BENAISSI, K., POLIAKOFF, M. and THOMAS, N. R., 2009. Green Chemistry. 11(5), 617-621
  • YANG, Y. Q. and THOMAS, N. R., 2009. Enzyme-mediated site-specific labelling of proteins with a new multipurpose biotin tag Amino Acids. 37, 120-120
  • BENAISSI, K., HOBBS, H. R., KIRKE, H. M., POLIAKOFF, M. and THOMAS, N. R., 2009. Solubilisation of proteins in fluorous solvents and supercritical carbon dioxide using hydrophobic ion pairing Olaj, Szappan, Kozmetika. 58(Spec.), 16-24
  • RACHED, O., TOWNSEND, A., KHIM, L., ROTH, S., STYLIANOU, E. and THOMAS, N. R., 2009. Identifying substrate specificity of a protein methyltransferase using a reverse chemical-genetics approach Amino Acids. 37, 124-124
  • BARDELANG, P., VANKEMMELBEKE, M., ZHANG, Y., JARVIS, H., ANTONIADOU, E., ROCHETTE, S., THOMAS, N.R., PENFOLD, C.N. and JAMES, R., 2009. Biochemical Journal. 418, 615-624
  • BEATON, S. A., HUESTIS, M. P., SADEGHI-KHOMAMI, A., THOMAS, N. R. and JAKEMAN, D. L., 2009. Enzyme-catalyzed synthesis of isosteric phosphono-analogues of sugar nucleotides Chemical Communications. 238-240
  • TURYANSKA, L., BRADSHAW, T.D., SHARPE, J., LI, M., MANN, S., THOMAS, N.R. and PATAN脠, A., 2009. Small. 5(15), 1738-1741
  • MANOLOPOULOS, P., GLENN, J.R., FOX, S.C., MAY, J.A., DOVLATOVA, N.L., TANG, S.-W., THOMAS, N.R., RALEVIC, V. and HEPTINSTALL, S., 2008. Platelets. 19(2), 134-145
  • ADKINS, S.S., HOBBS, H.R., BENAISSI, K., JOHNSTON, K.P., POLIAKOFF, M. and THOMAS, N.R., 2008. Journal of Physical Chemistry B. 112(15), 4760-4769
  • KONDOR, BETTI, GARCIA-SERNA, JUAN, POLIAKOFF, MARTYN, THOMAS, NEIL R. and COCERO, MARIA JOSE, 2008. Combi-CLEA for reactions in continuous flow supercritical CO2 AIChE Annual Meeting, Conference Proceedings, Philadelphia, PA, United States, Nov. 16-21, 2008. 45/1-45/10
  • HENNEQUIN, B., TURYANSKA, L., BEN, T., BELTR脕N, A.M., MOLINA, S.I., LI, M., MANN, S., PATAN脠, A. and THOMAS, N.R., 2008. Advanced Materials. 20(19), 3592鈥�3596
  • TURYANSKA, A., PATANE, A., HENINI, M., HENNEQUIN, B. and THOMAS, N.R., 2007. Applied Physics Letters. 90, 101913-101915
  • KOUVATSOS, N., THURSTON, V., BALL, K., OLDHAM, N.J., THOMAS, N.R. and SEARLE, M.S., 2007. Bile acid interactions with rabbit ileal lipid binding protein and an engineered helixless variant reveal novel ligand binding properties of a versatile beta-clam shell protein scaffold Journal of Molecular Biology. 371(5), 1365-1377
  • HOBBS, H.R., KIRKE, H.M., POLIAKOFF, M. and THOMAS, N.R., 2007. Angewandte Chemie International Edition. 46(41), 7860-7863
  • HOBBS, H.R. and THOMAS, N.R., 2007. Biocatalysis in supercritical fluids, in fluorous solvents, and under solvent-free conditions Chemical Reviews. 107(6), 2786-2820
  • WARFIELD, RACHEL, BARDELANG, PHILIP, SAUNDERS, HELEN, CHAN, WENG C, PENFOLD, CHRISTOPHER, JAMES, RICHARD and THOMAS, NEIL R, 2006. Organic and Biomolecular Chemistry. 4(19), 3626-38
  • KOUVATSOS, N., MELDRUM, J.K., SEARLE, M.S. and THOMAS, N.R., 2006. Chemical Communications. 44, 4623-4625
  • THOMAS, NEIL R, 2006. Histone post-translational modification: from discovery to the clinic. IDrugs. 9(6), 398-401
  • LE TRONG, ISOLDE, AUBERT, DIMITRI G L, THOMAS, NEIL R and STENKAMP, RONALD E, 2006. Acta Crystallographica. Section D: Biological Crystallography. 62(Pt 6), 576-81
  • SADEGHI-KHOMAMI, A., THOMAS, N.R. and WILSON, C., 2006. Acta Crystallographica. Section E. 62, 3759-3761
  • HOBBS, H. R., KONDOR, B., STEPHENSON, P., SHELDON, R. A., THOMAS, N. R. and POLIAKOFF, M., 2006. GREEN CHEMISTRY. VOL 8(NUMBER 9), 816-821
  • CHING, Y.-H., GHOSH, T.K., CROSS, S.J., PACKHAM, E.A., HONEYMAN, L., LOUGHNA, S., ROBINSON, T.E., DEARLOVE, A.M., RIBAS, G., BONSER, A.J., THOMAS, N.R., SCOTTER, A.J., CAVES, L.S.D., TYRRELL, G.P., NEWBURY-ECOB, R.A., MUNNICH, A., BONNET, D. and BROOK, J.D., 2005. Nature Genetics. 37(4), 423-428
  • CREN, S., WILSON, C. and THOMAS, N.R., 2005. Organic Letters. 7(16), 3521-3523
  • SADEGHI-KHOMAMI, A., BLAKE, A. J., WILSON, C. and THOMAS, N. R., 2005. Organic Letters. VOL 7(NUMB 22), 4891-4894
  • THOMAS, N.R., 2005. Frederic Stanley Kipping:Biography: International Rubber Science Hall of Fame Inductee Rubber Chemistry & Technology. 78, G2-G4
  • CREN, S., GURCHA, S.S., BLAKE, A.J., BESRA, G.S. and THOMAS, N.R., 2004. Organic and Biomolecular Chemistry. 2(17), 2418-2420
  • BENEDETTI, F., BERTI, F., BRADY, K., COLOMBATTI, A., PAULETTO, A., PUCILLO, C. and THOMAS, N. R., 2004. ChemBioChem. VOL 5(NUMB 1), 129-131
  • CROSS, S.S.J., BRADY, K., STEVENSON, J.D., SACKIN, J.R., KENWARD, N., DIETEL, A. and THOMAS, N.R., 2002. Journal of Immunological Methods. 269(1-2), 173-195
  • JOHNSON, H.A. and THOMAS, N.R., 2002. Bioorganic & Medicinal Chemistry Letters. 12(2), 237-241
  • BLAKE, A. J., DE, B. B., LI, W.-S. and THOMAS, N. R., 2002. Acta Crystallographica. Section C: Crystal Structure Communications. VOL 58(PART 12), m570-m574
  • THOMAS, NEIL R., 2002. Drugs: A Very Short Introduction. By Leslie Iverson
  • BLAKE,A.J., DIETEL,A., LI,W-S. and THOMAS,N.R., 2001. Acta Crystallographica. Section E: Structure Reports Online. 57(8), o790-o791
  • STEVENSON, JAMES D. and THOMAS, NEIL R., 2000. Catalytic antibodies and other biomimetic catalysts Natural Product Reports. 17(6), 535-577
  • SMITH, R. D. and THOMAS, N. R., 2000. A Convenient Synthesis of N-substituted Trihydroxypiperidines from Bis-Epoxides: Nucleophilic Opening of 1,2:4,5-Dianhydropentitols Synlett. PART 2, 193-196
  • THOMAS,N.R. and MANN,J., 2000. The Chemistry of Life. In: LISTER,T., ed., Cutting Edge Chemistry RSC Publications, London, UK. 177-196
  • STEVENSON, JAMES D., DIETEL, ANJA and THOMAS, NEIL R., 1999. A chemiluminescent catalytic antibody. [Erratum to document cited in CA132:46638] Chemical Communications (Cambridge). 2441
  • DE, BINOD B. and THOMAS, NEIL R., 1997. Optimization of the retroracemization procedure for alpha -amino acids using (S)-2-[(N-alkylprolyl)amino]benzophenones, recyclable chiral auxiliaries Tetrahedron: Asymmetry. 8(16), 2687-2691
  • THOMAS, NEIL R., 1996. Catalytic antibodies-reaching adolescence? Natural Product Reports. 13(6), 479-511
  • STAAHL, M., GOLDIE, B., BOURNE, S. P. and THOMAS, N. R., 1995. Catalytic Antibodies Generated By in Vitro Immunization Journal of the American Chemical Society. VOL 117(NUMBER 18), 5164
  • STEWART, JON D., ROBERTS, VICTORIA A., THOMAS, NEIL R., GETZOFF, ELIZABETH D. and BENKOVIC, STEPHEN J., 1994. Site-Directed Mutagenesis of a Catalytic Antibody: An Arginine and a Histidine Residue Play Key Roles Biochemistry. 33(8), 1994-2003
  • THOMAS, NEIL R., 1994. Hapten design for the generation of catalytic antibodies Applied Biochemistry and Biotechnology. 47(2-3), 345-72
  • THOMAS, NEIL R., SCHIRCH, VERNE and GANI, DAVID, 1993. Stereochemical course of the decarboxylation of 2-amino-2-methylmalonic acid by serine hydroxymethyltransferase Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999). 2925-31
  • ARCHER, CATHERINE H., THOMAS, NEIL R. and GANI, DAVID, 1993. Syntheses of (2S,3R)- and (2S,3R)[3-2H]-3-methylaspartic acid: slow substrates for a syn-elimination reaction catalyzed by methylaspartase Tetrahedron: Asymmetry. 4(6), 1141-52
  • THOMAS, NEIL R., ROSE, JANET E. and GANI, DAVID, 1993. Decarboxylation of 2-aminomalonic acid by serine hydroxymethyltransferase is, in fact, a stereospecific process Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999). 2933-7
  • BOTTING, NIGEL P., AKHTAR, MAHMOUD, ARCHER, CATHERINE H., COHEN, MARK A., THOMAS, NEIL R., GODA, SAYED, MINTON, NIGEL P. and GANI, DAVID, 1992. Catalytic mechanism and active-site structure of methylaspartate ammonia-lyase: Possible involvement of an electrophilic dehydroalanine reaction center Special Publication - Royal Society of Chemistry. 111(Molecular Recognition: Chemical and Biochemical Problems II), 95-109
  • THOMAS, NEIL R., ROSE, JANET E. and GANI, DAVID, 1991. Decarboxylation of 2-aminomalonic acid catalyzed by serine hydroxymethyltransferase is, in fact, a stereospecific process Journal of the Chemical Society, Chemical Communications. 908-9
  • THOMAS, NEIL R. and GANI, DAVID, 1991. Synthesis of (2R)- and (2S)-[1-13C)-2-amino-2-methylmalonic acid: chiral substrates for serine hydroxymethyltransferase Tetrahedron. 47(3), 497-506
  • THOMAS, NEIL R. and GANI, DAVID, 1991. Stereochemical fidelity of the aminomalonic acid decarboxylase activity of serine hydroxymethyltransferase Enzymes Depend. Pyridoxal Phosphate Other Carbonyl Compd. Cofactors, Proc. Int. Symp. Vitam. B6 Carbonyl Catal., 8th. 245-7
  • SMITH, D. M., THOMAS, N. R. and GANI, D., 1991. Experientia. 47(11-12), 1104-18
  • THOMAS, NEIL R., SCHIRCH, VERNE and GANI, DAVID, 1990. Synthesis of (2R)- and (2S)-[1-13C]-2-amino-2-methylmalonic acid, probes for the serine hydroxymethyltransferase reaction. Stereospecific decarboxylation of the 2-pro-R-carboxy group with the retention of configuration Journal of the Chemical Society, Chemical Communications. 400-2
  • BLOYCE, PETER E., CAMPEN, ANDREW K., HOOKER, RICHARD H., REST, ANTONY J., THOMAS, NEIL R., BITTERWOLF, THOMAS E. and SHADE, JOYCE E., 1990. Photochemistry of some iron and ruthenium (h5-cyclopentadienyl) carbonyl dimers in frozen gas matrices at ca. 12 K Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999). 2833-41

Centre for Cancer Sciences

The 糖心原创
Centre for Biomolecular Sciences
Nottingham, NG7 2RD


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