ÌÇÐÄÔ­´´

Contact

• workRoom C24 School of Chemistry
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 9513566
• fax0115 9513564
• james.dowden@nottingham.ac.uk

Biography

Dr. Dowden gained a B.Sc in Chemistry from the University of Sheffield in 1993, then moved to the University of Southampton and completed a PhD under the supervision of Prof. J. D. Kilburn in 1996. He then worked as a postdoc with Professors N. J. Turner and S. L. Flitsch at the Edinburgh Centre for Protein Technology within the Chemistry Department, University of Edinburgh for two and a half years. In 1999 he was appointed as Lecturer in Medicinal Chemistry at the University of Bath. In 2005 he moved to his present position of Lecturer in Chemical Biology at the ÌÇÐÄÔ­´´.

Research Summary

Development of expedient synthesis of natural products. Developments of new synthetic methods, especially utilising pyridinium salts or beta-lactams.

Design and synthesis of new enyzyme inhibitors. Especially development of novel inhibitors for protein methyltransferases.

Design and synthesis of chemical probes for biological systems; Divergent synthesis; Synthesis and evaluation of signalling nucleotides and analogues; Characterisation and modulation of Protein-Protein Interactions; Protein Tyrosine Phosphatases; Developmental Biology.

Selected Publications

• DAY, JONATHAN, MCKEEVER-ABBAS, BEN and DOWDEN, JAMES, 2016. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 55(19), 5809-5813

• View all publications

• DAY, JONATHAN, MCKEEVER-ABBAS, BEN and DOWDEN, JAMES, 2016. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 55(19), 5809-5813
• HANSON-HEINE, MAGNUS W. D., WRIGLESWORTH, ALISDAIR, UROOS, MALIHA, CALLADINE, JAMES A., MURPHY, THOMAS S., HAMILTON, MICHELLE, CLARK, IAN P., TOWRIE, MICHAEL, DOWDEN, JAMES, BESLEY, NICHOLAS A. and GEORGE, MICHAEL W., 2015. JOURNAL OF CHEMICAL PHYSICS. 142(15),
• YOU, B., HAMER, K., LEWIS, W. and DOWDEN, J., 2013. Chemical Communications. 49(8), 795-797
• DAY, JONATHAN, UROOS, MALIHA, CASTLEDINE, RICHARD A, LEWIS, WILLIAM, MCKEEVER-ABBAS, BEN and DOWDEN, JAMES, 2013. Organic & biomolecular chemistry. 11(38), 6502-9
• DOWDEN, J., PIKE, R.A., PARRY, R.V., HONG, W., MUHSEN, U.A. and WARD, S.G., 2011. Organic and Biomolecular Chemistry. 9(22), 7814-7821
• STEVENSON, B., LEWIS, W. and DOWDEN, J., 2010. Synlett. NUMB 4, 672-674
• DOWDEN, J., HONG, W., PARRY, R.V., PIKE, R.A. and WARD, S.G., 2010. Bioorganic and Medicinal Chemistry Letters. 20(7), 2103–2105
• DAMMERMANN, W., ZHANG, B., NEBEL, M., CORDIGLIERI, C., ODOARDI, F., KIRCHBERGER, T., KAWAKAMI, N., DOWDEN, J., SCHMID, F., DORNMAIR, K., HOHENEGGER, M., FLÃœGEL, A., GUSE, A.H. and POTTER, B.V.L., 2009. Proceedings of the National Academy of Sciences of the United States of America. 106(26), 10678-10683
• PARKESH, R., LEWIS, A.M., ALEY, P.K., ARREDOUANI, A., ROSSI, S., TAVARES, R., VASUDEVAN, S.R., ROSEN, D., GALIONE, A., DOWDEN, J. and CHURCHILL, G.C., 2008. Cell Calcium. 43(6), 531–538
• FOSTER, S.R., PEARCE, A., BLAKE, A.J., WELHAM, M.J. and DOWDEN, J., 2007. Chemical Communications. 24, 2512-2514
• ANDERSON, C., BARTLETT, S.J., GANSNER, J.M., WILSON, D., HE, L., GITLIN, J.D., KELSH, R.N. and DOWDEN, J., 2007. Molecular BioSystems. 3(1), 51-59
• PARKESH, RAMAN, VASUDEVAN, SRIDHAR R, BERRY, ALEXANDRA, GALIONE, ANTONY, DOWDEN, JAMES and CHURCHILL, GRANT C, 2007. Organic and Biomolecular Chemistry. 5(3), 441-3
• DOWDEN, J., BERRIDGE, G., MOREAU, C., YAMASAKI, M., CHURCHILL, G.C., POTTER, B.V.L. and GALIONE, A., 2006. Chemistry & Biology. 13(6), 659-665
• YIAKOUVAKI, A., SAVOVIĆ, J., AL-QENAEI, A., DOWDEN, J. and POURZAND, C., 2006. Journal of Investigative Dermatology. 126(10), 2287-2295
• POTTER,B.V.L., DOWDEN,J. and GALIONE,A., 2005. Therapeutics WO2005054198-A2 06/01/2005 00:00:00
• DOWDEN,J., BROWN,R.S., MOREAU,C., GALIONE,A. and POTTER,B.V., 2005. Nucleosides, Nucleotides and Nucleic Acids. 24(5-7), 513-518
• DOWDEN, J., MOREAU, C., BROWN, R.S., BERRIDGE, G., GALIONE, A. and POTTER, B.V.L., 2004. Angewandte Chemie International Edition. 43(35), 4637-4640
• GALIONE, A., PARRINGTON, J. and DOWDEN, J., 2004. British Journal of Pharmacology. VOL 142(PART 8), 1203-1208
• WARD,S., SOTSIOS,Y., DOWDEN,J., BRUCE,I. and FINAN,P., 2003. Chemistry & Biology. 10(3), 207-213
• BROWN, R. S., DOWDEN, J., MOREAU, C. and POTTER, B. V., 2002. Tetrahedron Letters. VOL 43(NUMBER 37), 6561 - 6562
• YANG, J., DOWDEN, J., TATIBOUET, A., HATANAKA, Y. and HOLMAN, G. D., 2002. Biochemical Journal. VOL 367(PART 2), 533-539
• DOWDEN, J. and SAVOVIĆ, J., 2001. Chemical Communications. 1, 37-38
• DOWDEN,J. and WARD,S.G., 2001. Expert Opinion on Therapeutic Patents. 11(2), 295-306