糖心原创

Contact

• workRoom D15 糖心原创 Medical School
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 82 30122
• fax0115 82 30103
• ian.kerr@nottingham.ac.uk

Teaching Summary

I'm the Director of the Biochemistry Courses ad so have overall responsibility for programme design and delivery. Specifically I convene a module in year 2 that aim to showcase how experimental… read more

Research Summary

My research interests are the mechanisms and structures of proteins involved in transmembrane flux.

In particular, the group works on ATP binding cassette (ABC) transporters which are involved in multidrug efflux from cancer cells, and which are involved in the clinical drug resistance of many tumour types. We have a BBSRC funded project to investigate the pharmacology of ABCG2 in collaboration with Nicholas Holliday and Steve Briddon. We have strong collaborations with the group of Beth Coyle to understand the role played by ABC transporters in pediatric brain tumour drug drug resistance, and with the group of to understand the mechanism of human ABC proteins.

More broadly I am interested in all types of transporter proteins and have previously worked on plant auxin transporters and bacterial multidrug pumps. Some very related proteins are involved in ribosomal control (too long a story for here) and I've had a long-standing interest in those.

Methods for studying membrane proteins continue to improve and I've worked with several groups to help improve protein purification for functional activity.

More broadly I am interested in all types of transporter proteins and have previously worked on plant auxin transporters and bacterial multidrug pumps. Some very related proteins are involved in ribosomal control (too long a story for here) and I've had a long-standing interest in those.

Methods for studying membrane proteins continue to improve and I've worked with several groups to help improve protein purification for functional activity.

Selected Publications

• SABNIS, DURGAGAURI H., STORER, LISA C. D., LIU, JO-FEN, JACKSON, HANNAH K., KILDAY, J. P., GRUNDY, RICHARD G., KERR, IAN D. and COYLE, BETH, 2019. SCIENTIFIC REPORTS. 9,
• COX, MEGAN H., KAPOOR, PARTH, BRIGGS, DEBORAH A. and KERR, IAN D., 2018. BIOCHEMICAL JOURNAL. 475, 1553-1567
• MITTRA R, PAVY M, SUBRAMANIAN N, GEORGE AM, O'MARA ML, KERR ID and CALLAGHAN R, 2017. Biochemical pharmacology. 123, 19-28
• WONG, KELVIN, BRIDDON, STEPHEN J., HOLLIDAY, NICHOLAS D. and KERR, IAN D., 2016. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 1863(1), 19-29

• View all publications

I'm the Director of the Biochemistry Courses ad so have overall responsibility for programme design and delivery. Specifically I convene a module in year 2 that aim to showcase how experimental design and analysis can determine correlations and causation between genotype and phenotype. I also make significant contributions to a year 2 proteins module, to a year 3 diabetes and obesity module and run a 3rd year research project for 10-12 students invesitgating bacterial drug pump proteins

• SABNIS, DURGAGAURI H., STORER, LISA C. D., LIU, JO-FEN, JACKSON, HANNAH K., KILDAY, J. P., GRUNDY, RICHARD G., KERR, IAN D. and COYLE, BETH, 2019. SCIENTIFIC REPORTS. 9,
• COX, MEGAN H., KAPOOR, PARTH, BRIGGS, DEBORAH A. and KERR, IAN D., 2018. BIOCHEMICAL JOURNAL. 475, 1553-1567
• KAPOOR, PARTH, HORSEY, AARON J., COX, MEGAN H. and KERR, IAN D., 2018. BIOCHEMICAL SOCIETY TRANSACTIONS. 46, 1485-1494
• HEYES, NIALL, KAPOOR, PARTH and KERR, IAN D., 2018. DRUG METABOLISM AND DISPOSITION. 46(12), 1886-1899
• MITTRA R, PAVY M, SUBRAMANIAN N, GEORGE AM, O'MARA ML, KERR ID and CALLAGHAN R, 2017. Biochemical pharmacology. 123, 19-28
• WONG, KELVIN, BRIDDON, STEPHEN J., HOLLIDAY, NICHOLAS D. and KERR, IAN D., 2016. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 1863(1), 19-29
• AL-GHAFARI, A. B., PUNJARUK, W., STORER, L. C. D., CARRIER, D. J., HUSSEIN, D., COYLE, B. and KERR, I. D., 2016. JOURNAL OF NEURO-ONCOLOGY. 127(3), 455-462
• HORSEY AJ, COX MH, SARWAT S and KERR ID, 2016. Biochemical Society transactions. 44(3), 824-30
• THEODOULOU, FREDERICA L. and KERR, IAN D., 2015. BIOCHEMICAL SOCIETY TRANSACTIONS. 43, 1033-1040
• COYLE, BETH, KESSLER, MAYA, SABNIS, DURGAGAURI H. and KERR, IAN D., 2015. BIOCHEMICAL SOCIETY TRANSACTIONS. 43, 1018-1022
• DARBY, RICHARD A. J., UNSWORTH, AMANDA, KNAPP, STEFAN, KERR, IAN D. and CALLAGHAN, RICHARD, 2015. CANCER CHEMOTHERAPY AND PHARMACOLOGY. 76(4), 853-864
• HAIDER AJ, COX MH, JONES N, GOODE AJ, BRIDGE KS, WONG K, BRIGGS D and KERR ID, 2015. Bioscience reports. 35(4),
• POLLOCK NL, MCDEVITT CA, COLLINS R, NIESTEN PHM, PRINCE S, KERR ID, FORD RC and CALLAGHAN R, 2014. Biochimica et biophysica acta. 1838(1 Pt B), 134-47
• WONG K, MA J, ROTHNIE A, BIGGIN PC and KERR ID, 2014. Trends in biochemical sciences. 39(1), 8-16
• VAN WONDEREN JH, MCMAHON RM, O'MARA ML, MCDEVITT CA, THOMSON AJ, KERR ID, MACMILLAN F and CALLAGHAN R, 2014. The FEBS journal. 281(9), 2190-201
• GULATI S, JAMSHAD M, KNOWLES TJ, MORRISON KA, DOWNING R, CANT N, COLLINS R, KOENDERINK JB, FORD RC, OVERDUIN M, KERR ID, DAFFORN TR and ROTHNIE AJ, 2014. The Biochemical journal. 461(2), 269-78
• OTHMAN RT, KIMISHI I, BRADSHAW TD, STORER LCD, KORSHUNOV A, PFISTER SM, GRUNDY RG, KERR ID and COYLE B, 2014. Acta neuropathologica communications. 2, 57
• DE MARCOS LOUSA C, VAN ROERMUND CWT, POSTIS VLG, DIETRICH D, KERR ID, WANDERS RJA, BALDWIN SA, BAKER A and THEODOULOU FL, 2013. Proceedings of the National Academy of Sciences of the United States of America. 110(4), 1279-84
• KAY, C., WOODWARD, K.D., LAWLER, K., SELF, T.J., DYALL, S.D. and KERR, I.D., 2012. PLoS Neglected Tropical Diseases. 6(6), e1693
• KAY, C., LAWLER, K., SELF, T. J., DYALL, S. D. and KERR, I. D., 2012. FEBS Lett. 586(22), 4038-45
• DORRIAN JM, BRIGGS DA, RIDLEY ML, LAYFIELD R, KERR ID, 2011. FEBS Journal. 278(21), 4015-24
• DE SMET, IVE, VOSS, UTE, LAU, STEFFEN, WILSON, MICHAEL, SHAO, NING, TIMME, RUTH, SWARUP, RANJAN, KERR, IAN, HODGMAN, CHARLIE, BOCK, RALPH, BENNETT, MALCOLM, J脺RGENS, GERD and BEECKMAN, TOM, 2011. Plant Physiology. 155, 209-221
• HAIDER, A.J., BRIGGS, D., SELF, T.J., CHILVERS, H.L., HOLLIDAY, N.D. and KERR, I.D., 2011. PLoS ONE. 6(10), e25818
• KERR ID, HAIDER AJ and GELISSEN IC, 2011. British Journal Of Pharmacology. 164(7), 1767-79
• HUSSEIN, D., PUNJARUK, W., STORER, L.C.D., SHAW, L., OTHMAN, R.T., PEET, A., MILLER, S., BANDOPADHYAY, G., HEATH, R., KUMARI, R., BOWMAN, K.J., BRAKER, P., RAHMAN, R., JONES, G.D.D. and WATSON, S., 2010. Neuro-oncology. 13(1), 70-83
• CROWLEY, EMILY, O'MARA, MEGAN L, KERR, IAN D and CALLAGHAN, RICHARD, 2010. The FEBS journal. 277(19), 3974-85
• KERR, IAN D, JONES, PETER M and GEORGE, ANTHONY M, 2010. The FEBS journal. 277(3), 550-63
• CHUTHAPISITH, S, BEAN, B, COWLEY, G, EREMIN, JM, SAMPHAO, S, LAYFIELD, R, KERR, ID, WISEMAN, J, EL-SHEEMY, M, SREENIVASAN, T, EREMIN, O, 2009. European Journal of Cancer. 45(7), 1274-81
• CROWLEY, EMILY, O'MARA, MEGAN L, REYNOLDS, CATHERINE, TIELEMAN, D PETER, STORM, JANET, KERR, IAN D and CALLAGHAN, RICHARD, 2009. Biochemistry. 48(26), 6249-58
• FORD, R.C, KAMIS, A, KERR, I.D and & CALLAGHAN, R., 2009. The ABC Transporters: Structural insights into drug transport. In: ECKER, G and CHIBA, P. &MANNHOLD, R., eds., Transporters as Drug Carriers: Structure, Function, Substrates Wiley. 3-49
• CARRIER, DAVID JOHN, ABU BAKAR, NORLIZA TENDOT, LAWLER, KAREN, DORRIAN, JAMES MATTHEW, HAIDER, AMEENA, BENNETT, MALCOLM JOHN and KERR, IAN DEREK, 2009. Heterologous Expression of a Membrane-Spanning Auxin Importer: Implications for Functional Analyses of Auxin Transporters. International journal of plant genomics. 2009, 848145
• DORRIAN J.M. & KERR, I.D., 2009. Can ABC proteins confer drug resistance in micro-organisms without being export pumps?. In: PONTE-SUCRE, A., ed., ABC Transporters in Microorganisms Horizon Press. 45-54
• MCDEVITT, CHRISTOPHER A, COLLINS, RICHARD, KERR, IAN D and CALLAGHAN, RICHARD, 2009. Advanced drug delivery reviews. 61(1), 57-65
• SWARUP, K., BENKOV脕, E., SWARUP, R., CASIMIRO, I., P脡RET, B., YANG, Y., PARRY, G., NIELSEN, E., DE SMET, I., VANNESTE, S., LEVESQUE, M., CARRIER, D., JAMES, N., CALVO, V. and LJUNG, K., 2008. Nature Cell Biology. 10(8), 946-954
• CARRIER, D.J., ABU BAKAR, N.T., SWARUP, R., CALLAGHAN, R., NAPIER, R.M., BENNETT, M.J. and KERR, I.D., 2008. Plant Physiology. 148(1), 529-535
• STORM, JANET, MODOK, SZABOLCS, O'MARA, MEGAN L, TIELEMAN, D PETER, KERR, IAN D and CALLAGHAN, RICHARD, 2008. Biochemistry. 47(12), 3615-24
• MCDEVITT,, CROWLEY,, HOBBS,, STARR,, KERR, and CALLAGHAN,, 2008. The FEBS Journal.
• LAWSON, J, O'MARA, M L and KERR, I D, 2008. Structure-based interpretation of the mutagenesis database for the nucleotide binding domains of P-glycoprotein. Biochimica et Biophysica Acta. 1778(2), 376-91
• CALLAGHAN, RICHARD, CROWLEY, EMILY, POTTER, SIMON and KERR, IAN D, 2008. Journal of Clinical Pharmacology. 48(3), 365-78
• CHUTHAPISITH, S, LAYFIELD, R, KERR, I D and EREMIN, O, 2007. The Surgeon. 5(1), 14-22
• CHUTHAPISITH, S, LAYFIELD, R, KERR, ID, HUGHES, C, EREMIN, O, 2007. Proteomic profiling of MCF-7 breast cancer cells with chemoresistance to different types of anti-cancer drugs. International Journal of Oncology. 30(6), 1545-51
• WARNER,, VADOLIA,, LAUGHTON,, KERR, and DOUGHTY,, 2007. Journal of Molecular Graphics and Modelling. 26, 691-699
• KERR, IAN D and BENNETT, MALCOLM J, 2007. Biochemical Journal. 401(3), 613-22
• STORM,, O'MARA,, CROWLEY,, PEALL,, TIELEMAN,, KERR, and CALLAGHAN,, 2007. Biochemistry. 46(35), 9899-9910
• CLARK, R, KERR, I D and CALLAGHAN, R, 2006. British Journal of Pharmacology. 149(5), 506-15
• KERR, I. D. and SIMPKINS, N. S., 2006. LETTERS IN DRUG DESIGN AND DISCOVERY. VOL 3(NUMB 9), 607-621
• MCDEVITT, CHRISTOPHER A, COLLINS, RICHARD F, CONWAY, MICHAEL, MODOK, SZABOLCS, STORM, JANET, KERR, IAN D, FORD, ROBERT C and CALLAGHAN, RICHARD, 2006. Structure. 14(11), 1623-32
• CALLAGHAN, RICHARD, FORD, ROBERT C and KERR, IAN D, 2006. FEBS Letters. 580(4), 1056-63
• ROTHNIE, A., STORM, J., MCMAHON, R., TAYLOR, A., KERR, I.D. and CALLAGHAN, R, 2005. FEBS Letters. 579(18), 3984-3990
• KERR, I D, REYNOLDS, E D and COVE, J H, 2005. Biochemical Society Transactions. 33(Pt 5), 1000-2
• SWARUP, R., KARGUL, J., MARCHANT, A., ZADIK, D., RAHMAN, A., MILLS, R., YEMM, A., MAY, S., WILLIAMS, L., MILLNER, P., TSURUMI, S., MOORE, I., NAPIER, R., KERR, I.D. and BENNETT, M.J., 2004. Plant Cell. 16(11), 3069-3083
• ROTHNIE, A., STORM, J., CAMPBELL, J., LINTON, K.J., KERR, I.D. and CALLAGHAN, R, 2004. Journal of Biological Chemistry. 279(33), 34913-34921
• KERR, I.D, 2004. Biochemical and Biophysical Research Communications. 315(1), 166-173
• CAMPBELL, JEFF D, DEOL, SUNDEEP SINGH, ASHCROFT, FRANCES M, KERR, IAN D and SANSOM, MARK S P, 2004. Biophysical Journal. 87(6), 3703-15
• STENHAM, D.R., CAMPBELL, J.D., SANSOM, M.S.P., HIGGINS, C.F., KERR, I.D. and LINTON, K.J., 2003. FASEB Journal. 17(15), 2287-2289
• BERRIDGE, G., WALKER, J. A., CALLAGHAN, R. and KERR, I. D., 2003. European Journal of Biochemistry. 270(7), 1483-1492
• KERR, IAN D, BERRIDGE, GEORGINA, LINTON, KENNETH J, HIGGINS, CHRISTOPHER F and CALLAGHAN, RICHARD, 2003. European Biophysics Journal. 32(7), 644-54
• GABRIEL, MARK P, STORM, JANET, ROTHNIE, ALICE, TAYLOR, ANDREW M, LINTON, KENNETH J, KERR, IAN D and CALLAGHAN, RICHARD, 2003. Biochemistry. 42(25), 7780-9
• KERR, IAN D, 2002. Biochimica et Biophysica Acta. 1561(1), 47-64
• ROSENBERG, M. F., VELARDE, G., FORD, R. C., MARTIN, C., BERRIDGE, G., KERR, I. D., CALLAGHAN, R., SCHMIDLIN, A., WOODING, C. and LINTON, K. J., 2001. EMBO Journal. VOL 20(PART 20), 5615-5625
• SON, H S, KERR, I D and SANSOM, M S, 2000. European Biophysics Journal. 28(8), 663-73
• RANATUNGA, K M, KERR, I D, ADCOCK, C A, SMITH, G R and SANSOM, M S, 1998. Molecular dynamics of ion/channel interactions. Biochemical Society Transactions. 26(3), S301
• SANSOM, M S, KERR, I D, LAW, R, DAVISON, L and TIELEMAN, D P, 1998. Biochemical Society Transactions. 26(3), 509-15
• RANATUNGA, K M, KERR, I D, ADCOCK, C, SMITH, G R and SANSOM, M S, 1998. Biochimica et Biophysica Acta. 1370(1), 1-7
• GRICE, A L, KERR, I D and SANSOM, M S, 1997. FEBS Letters. 405(3), 299-304
• KERR, I D and SANSOM, M S, 1997. Biophysical Journal. 73(2), 581-602
• SANSOM, M S, KERR, I D, SMITH, G R and SON, H S, 1997. Virology. 233(1), 163-73
• SCHMITT, J D, SANSOM, M S, KERR, I D, LUNT, G G and EISENTHAL, R, 1997. Biochemistry. 36(5), 1115-22
• BREED, J, BIGGIN, P C, KERR, I D, SMART, O S and SANSOM, M S, 1997. Biochimica et Biophysica Acta. 1325(2), 235-49
• BREED, J, KERR, I D, MOLLE, G, DUCLOHIER, H and SANSOM, M S, 1997. Biochimica et Biophysica Acta. 1330(2), 103-9