糖心原创

Contact

• workC209a, Biodiscovery Institute, Science Road, 糖心原创, NG7 2RD
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 823 1547
• Alan.Mcintyre@nottingham.ac.uk

Expertise Summary

My research focuses on understanding the molecular and cell biology of the hypoxic microenvironment. Hypoxia (low oxygen) is key in many pathological settings including wound healing, inflammation, ischemia and cancer. Regions of hypoxia in tumours are associated with worse survival, chemotherapy and radiotherapy resistance. Tumour hypoxia arises from the combination of high metabolic and proliferative rates and aberrant vascularisation. The hypoxic tumour microenvironment is also acidic as metabolic acid accumulates in poorly-vascularised areas. Hypoxia induces a transcriptome shift under the regulation of the transcription factors HIF1伪 and HIF2伪, which are stabilised in hypoxia. HIFs regulate genes in key "hallmarks of cancer" processes that enable adaptation to the hypoxic tumour microenvironment. In many cases anti-angiogenic therapy, such as bevacizumab, increases tumour hypoxia and hypoxic adaptation is a major mechanism of resistance to anti-angiogenic therapies. Understanding the molecular consequences of hypoxia and how to target hypoxic regions of tumours is key in improving tumour patient survival.

My research interests are:

Tumour Microenvironment Stress

Molecular Adaptive Responses

Epigenetics

Transcription

Metabolism

Acidosis

Translation

Angiogenesis

miRNAs

Invasion and metastasis

Functional shRNA/siRNA screens - Induced essentiality

Biomarkers

Cancer stem cells

Our work is generously funded by: The Medical Research Council, Breast Cancer Now and Bowel & Cancer Research.

I have a self-funded PhD studentship available for October 2020 start please contact me directly to find out more details.

Selected Publications

• HAIDER S, MCINTYRE A, VAN STIPHOUT RG, WINCHESTER LM, WIGFIELD S, HARRIS AL and BUFFA FM, 2016. Genome biology. 17(1), 140
• DA MOTTA, L. L., LEDAKI, I., PURSHOUSE, K., HAIDER, S., DE BASTIANI, M. A., BABAN, D., MOROTTI, M., STEERS, G., WIGFIELD, S., BRIDGES, E., LI, J. L., KNAPP, S., EBNER, D., KLAMT, F., HARRIS, A. L. and MCINTYRE, A., 2016. Oncogene.
• MCINTYRE, ALAN, HULIKOVA, ALZBETA, LEDAKI, IOANNA, SNELL, CAMERON, SINGLETON, DEAN, STEERS, GRAHAM, SEDEN, PETER, JONES, DYLAN, BRIDGES, ESTHER, WIGFIELD, SIMON, LI, JI-LIANG, RUSSELL, ANGELA, SWIETACH, PAWEL and HARRIS, ADRIAN L., 2016.
• HANI CHOUDHRY, ADRIAN L. HARRIS and ALAN MCINTYRE, 2016. Molecular Aspects of Medicine. 47-48, 35-53

• View all publications

• HANI CHOUDHRY, ADRIAN L. HARRIS and ALAN MCINTYRE, 2016. Molecular Aspects of Medicine. 47-48, 35-53
• MCINTYRE, ALAN, HULIKOVA, ALZBETA, LEDAKI, IOANNA, SNELL, CAMERON, SINGLETON, DEAN, STEERS, GRAHAM, SEDEN, PETER, JONES, DYLAN, BRIDGES, ESTHER, WIGFIELD, SIMON, LI, JI-LIANG, RUSSELL, ANGELA, SWIETACH, PAWEL and HARRIS, ADRIAN L., 2016.
• DA MOTTA, L. L., LEDAKI, I., PURSHOUSE, K., HAIDER, S., DE BASTIANI, M. A., BABAN, D., MOROTTI, M., STEERS, G., WIGFIELD, S., BRIDGES, E., LI, J. L., KNAPP, S., EBNER, D., KLAMT, F., HARRIS, A. L. and MCINTYRE, A., 2016. Oncogene.
• MCINTYRE A and HARRIS AL, 2016. Recent results in cancer research. Fortschritte der Krebsforschung. Progre虁s dans les recherches sur le cancer. 207, 93-134
• HAIDER S, MCINTYRE A, VAN STIPHOUT RG, WINCHESTER LM, WIGFIELD S, HARRIS AL and BUFFA FM, 2016. Genome biology. 17(1), 140
• LEEK R, GRIMES DR, HARRIS AL and MCINTYRE A, 2016. Advances in experimental medicine and biology. 899, 167-96
• GRIMES DR, KANNAN P, MCINTYRE A, KAVANAGH A, SIDDIKY A, WIGFIELD S, HARRIS A and PARTRIDGE M, 2016. PloS one. 11(4), e0153692
• MCINTYRE A and HARRIS AL, 2015. EMBO molecular medicine. 7(4), 368-379
• TAPMEIER, THOMAS T., MOSHNIKOVA, ANNA, BEECH, JOHN, ALLEN, DANNY, KINCHESH, PAUL, SMART, SEAN, HARRIS, ADRIAN, MCINTYRE, ALAN, ENGELMAN, DONALD M., ANDREEV, OLEG A., RESHETNYAK, YANA K. and MUSCHEL, RUTH J., 2015. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 112(31), 9710-9715
• GALLAGHER FA, SLADEN H, KETTUNEN MI, SERRAO EM, RODRIGUES TB, WRIGHT A, GILL A, MCGUIRE S, BOOTH TC, BOREN J, MCINTYRE A, MILLER JL, LEE S, HONESS D, DAY SE, HU D, HOWAT WJ, HARRIS AL and BRINDLE KM, 2015. Cancer research.
• IOANNA LEDAKI*, ALAN MCINTYRE*, SIMON WIGFIELD, FRANCESCA BUFFA, SIMON MCGOWAN, DILAIR BABAN and JI-LIANG LI, 2015. Carbonic anhydrase IX induction defines a heterogeneous cancer cell response to hypoxia and mediates stem cell-like properties and sensitivity to HDAC inhibition. Oncotarget. 6(23), 19413-19427
• SNELL, C. E., TURLEY, H., MCINTYRE, A., LI, D., MASIERO, M., SCHOFIELD, C. J., GATTER, K. C., HARRIS, A. L. and PEZZELLA, F., 2014. PLoS One. 9(2), e88955
• HARJES, U., BRIDGES, E., MCINTYRE, A., FIELDING, B. A. and HARRIS, A. L., 2014. J Biol Chem. 289(33), 23168-76
• WAGHORN, PHILIP A., JONES, MICHAEL W., MCINTYRE, ALAN, INNOCENTI, ALESSIO, VULLO, DANIELA, HARRIS, ADRIAN L., SUPURAN, CLAUDIU T. and DILWORTH, JONATHAN R., 2012. European Journal of Inorganic Chemistry. 2012(17), 2898-2907
• TONELLI, R., MCINTYRE, A., CAMERIN, C., WALTERS, Z. S., DI LEO, K., SELFE, J., PURGATO, S., MISSIAGLIA, E., TORTORI, A., RENSHAW, J., ASTOLFI, A., TAYLOR, K. R., SERRAVALLE, S., BISHOP, R., NANNI, C., VALENTIJN, L. J., FACCINI, A., LEUSCHNER, I., FORMICA, S., REIS-FILHO, J. S., AMBROSINI, V., THWAY, K., FRANZONI, M., SUMMERSGILL, B., MARCHELLI, R., HRELIA, P., CANTELLI-FORTI, G., FANTI, S., CORRADINI, R., PESSION, A. and SHIPLEY, J., 2012. Clin Cancer Res. 18(3), 796-807
• MCINTYRE, A., PATIAR, S., WIGFIELD, S., LI, J. L., LEDAKI, I., TURLEY, H., LEEK, R., SNELL, C., GATTER, K., SLY, W. S., VAUGHAN-JONES, R. D., SWIETACH, P. and HARRIS, A. L., 2012. Clin Cancer Res. 18(11), 3100-11
• FAVARO, E., BENSAAD, K., CHONG, M. G., TENNANT, D. A., FERGUSON, D. J., SNELL, C., STEERS, G., TURLEY, H., LI, J. L., GUNTHER, U. L., BUFFA, F. M., MCINTYRE, A. and HARRIS, A. L., 2012. Cell Metab. 16(6), 751-64
• GILBERT, D. C., MCINTYRE, A., SUMMERSGILL, B., MISSIAGLIA, E., GODDARD, N. C., CHANDLER, I., HUDDART, R. A. and SHIPLEY, J., 2011. Genes Chromosomes Cancer. 50(3), 186-95
• GILBERT, D. C., CHANDLER, I., SUMMERSGILL, B., MCINTYRE, A., MISSIAGLIA, E., GODDARD, N. C., HUDDART, R. A. and SHIPLEY, J., 2011. Int J Androl. 34(4 Pt 2), e114-21; discussion e121
• DUBOIS, L., PEETERS, S., LIEUWES, N. G., GEUSENS, N., THIRY, A., WIGFIELD, S., CARTA, F., MCINTYRE, A., SCOZZAFAVA, A., DOGNE, J. M., SUPURAN, C. T., HARRIS, A. L., MASEREEL, B. and LAMBIN, P., 2011. Radiother Oncol. 99(3), 424-31
• NOEL, E. E., YESTE-VELASCO, M., MAO, X., PERRY, J., KUDAHETTI, S. C., LI, N. F., SHARP, S., CHAPLIN, T., XUE, L., MCINTYRE, A., SHAN, L., POWLES, T., OLIVER, R. T., YOUNG, B. D., SHIPLEY, J., BERNEY, D. M., JOEL, S. P. and LU, Y. J., 2010. Am J Pathol. 176(6), 2607-15
• GODDARD, N. C., MCINTYRE, A., GILBERT, D., KITAZAWA, S. and SHIPLEY, J., 2010. Genes, Chromosomes and Cancer. 49(10), 963-966
• GILBERT, D. C., CHANDLER, I., MCINTYRE, A., GODDARD, N. C., GABE, R., HUDDART, R. A. and SHIPLEY, J., 2009. 217(1), 94-102
• STOOP, H., HONECKER, F., VAN DE GEIJN, G. J. M., GILLIS, A. J. M., COOLS, M. C., DE BOER, M., BOKEMEYER, C., WOLFFENBUTTEL, K. P., DROP, S. L. S., DE KRIJGER, R. R., DENNIS, N., SUMMERSGILL, B., MCINTYRE, A., SHIPLEY, J., OOSTERHUIS, J. W. and LOOIJENGA, L. H. J., 2008. The Journal of Pathology. 216(1), 43-54
• MCINTYRE, A., GILBERT, D., GODDARD, N., LOOIJENGA, L. and SHIPLEY, J., 2008. Genes Chromosomes Cancer. 47(7), 547-57
• MCINTYRE, A., SUMMERSGILL, B., LU, Y. J., MISSIAGLIA, E., KITAZAWA, S., OOSTERHUIS, J. W., LOOIJENGA, L. H. and SHIPLEY, J., 2007. Br J Cancer. 97(12), 1707-12
• GODDARD, N. C., MCINTYRE, A., SUMMERSGILL, B., GILBERT, D., KITAZAWA, S. and SHIPLEY, J., 2007. Int J Androl. 30(4), 337-48; discussion 349
• LOOIJENGA, L. H., HERSMUS, R., GILLIS, A. J., PFUNDT, R., STOOP, H. J., VAN GURP, R. J., VELTMAN, J., BEVERLOO, H. B., VAN DRUNEN, E., VAN KESSEL, A. G., PERA, R. R., SCHNEIDER, D. T., SUMMERSGILL, B., SHIPLEY, J., MCINTYRE, A., VAN DER SPEK, P., SCHOENMAKERS, E. and OOSTERHUIS, J. W., 2006. Cancer Res. 66(1), 290-302
• MCINTYRE, A., SUMMERSGILL, B., GRYGALEWICZ, B., GILLIS, A. J., STOOP, J., VAN GURP, R. J., DENNIS, N., FISHER, C., HUDDART, R., COOPER, C., CLARK, J., OOSTERHUIS, J. W., LOOIJENGA, L. H. and SHIPLEY, J., 2005. Cancer Res. 65(18), 8085-9
• MCINTYRE, ALAN, SUMMERSGILL, BRENDA, SPENDLOVE, HAYLEY E., HUDDART, ROBERT, HOULSTON, RICHARD and SHIPLEY, JANET, 2005. Neoplasia. 7(12), 1047-1052
• LU, YONG-JIE, YANG, JINSHU, NOEL, ELODIE, SKOULAKIS, SPYROS, CHAPLIN, TRACY, RAGHAVAN, MANOJ, PURKIS, TRISHA, MCINTYRE, ALAN, KUDAHETTI, SAKUNTHALA C., NAASE, MAHMOUD, BERNEY, DAN, SHIPLEY, JANET, OLIVER, R. TIMOTHY D. and YOUNG, BRYAN D., 2005. Cancer Res. 65(20), 9137-9141
• MCINTYRE, A., SUMMERSGILL, B., JAFER, O., RODRIGUEZ, S., ZAFARANA, G., OOSTERHUIS, J. W., GILLIS, A. J., LOOIJENGA, L., COOPER, C., HUDDART, R., CLARK, J. and SHIPLEY, J., 2004. Oncogene. 23(56), 9142-7