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Laura Hobley

Assistant Professor, Faculty of Science

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Biography

Dr Laura Hobley is an Assistant Professor of Microbiology within the Food Sciences Division in the School of Biosciences. She graduated with a BSc(Hons) in Mathematics from the 糖心原创 in 2003, and then completed a PhD joint between the 糖心原创's School of Mathematical Sciences and the Institute of Genetics under the supervision of Profs John King and Liz Sockett, working on the predatory bacterium Bdellovibrio. She continued working in the lab of Prof Sockett as a postdoc, working on various aspects of Bdellovibrio biology, including the first in vivo animal trials of Bdellovibrio therapy, and was involved in several studies looking at the molecular basis of predation. In 2012 she moved to work as a postdoc in the group of Prof Nicola Stanley-Wall at the University of Dundee, working on biofilm formation by Gram-positive bacteria, primarily studying the function of the biofilm matrix protein BslA during biofilm formation by Bacillus subtilis. In addition she studied the roles of polyamines in regulating biofilm formation in Bacillus. In 2015 she took up a Queens University Research Fellowship to set up her own research group at Queens University Belfast, working on biofilm formation by Klebsiella pneumoniae. In 2018, she moved her research to the 糖心原创, where her research includes biofilm formation by multi-drug resistant Gram-negative pathogens, particularly Klebsiella pneumoniae and Acinetobacter baumannii, and the role of biofilm formation in antibiotic resistance and virulence. A growing area of interest of her research group is on bacterial predation by Bdellovibrio, including investigating the molecular processes involved in predation, therapeutic applications and environmental bioremediation.

Research Summary

Research in the Hobley lab focuses on cell:cell interactions between bacteria, between bacteria and viruses, and between bacteria and host cells. A primary area that we are investigating is the… read more

Recent Publications

  • ARNAOUTELI, S., BAMFORD, N. C., BRANDANI, G. B., MORRIS, R. J., SCHOR, M., CARRINGTON, J. T., HOBLEY, L., VAN AALTEN, D. M. F., STANLEY-WALL, N. R. and MACPHEE, C. E., 2023. Proc Natl Acad Sci U S A. 120(45), e2312022120
  • HOBLEY, LAURA, SUMMERS, J KIMBERLEY, TILL, ROB, MILNER, DAVID S, ATTERBURY, ROBERT J, STROUD, AMY, CAPENESS, MICHAEL J, GRAY, STEPHANIE, LEIDENROTH, ANDREAS, LAMBERT, CAREY, CONNERTON, IAN, TWYCROSS, JAMIE, BAKER, MICHELLE, TYSON, JESS, KREFT, JAN-ULRICH and SOCKETT, R ELIZABETH, 2020. Journal of Bacteriology. 202(6), e00629-19
  • STOREY, D., MCNALLY, A., ASTRAND, M., SA-PESSOA GRACA SANTOS, J., RODRIGUEZ-ESCUDERO, I., ELMORE, B., PALACIOS, L., MARSHALL, H., HOBLEY, L., MOLINA, M., CID, V. J., SALMINEN, T. A. and BENGOECHEA, J. A., 2020. PLoS Pathog. 16(3), e1007969
  • SA-PESSOA, J., PRZYBYSZEWSKA, K., VASCONCELOS, F. N., DUMIGAN, A., FRANK, C. G., HOBLEY, L. and BENGOECHEA, J. A., 2020. MBio. 11(5),

Current Research

Research in the Hobley lab focuses on cell:cell interactions between bacteria, between bacteria and viruses, and between bacteria and host cells. A primary area that we are investigating is the bacteria predator Bdellovibrio, which eats other bacteria from the inside. We are interested in the molecular processes that allow predation, to understand how Bdellovibrio has evolved to live a predatory lifecycle. Our research also includes therapeutic applications of Bdellovibrio to control bacterial pathogens, and potential environmental bioremediation uses of Bdellovibrio. We are also working to understand the molecular basis underlying biofilm formation by Gram-negative, multi-drug resistant bacterial pathogens. The labs primary focus is on the pathogens Klebsiella pneumoniae and Acinetobacter baumannii. An interdisciplinary approach is used to study biofilm formation, involving bacterial genetics, biochemistry, mathematical modelling and biophysics as appropriate. We also have interests in the uses of bacteriophage, both as independent biological control agents, and also from the perspective of combinatorial uses alongside predatory bacteria.

  • ARNAOUTELI, S., BAMFORD, N. C., BRANDANI, G. B., MORRIS, R. J., SCHOR, M., CARRINGTON, J. T., HOBLEY, L., VAN AALTEN, D. M. F., STANLEY-WALL, N. R. and MACPHEE, C. E., 2023. Proc Natl Acad Sci U S A. 120(45), e2312022120
  • HOBLEY, LAURA, SUMMERS, J KIMBERLEY, TILL, ROB, MILNER, DAVID S, ATTERBURY, ROBERT J, STROUD, AMY, CAPENESS, MICHAEL J, GRAY, STEPHANIE, LEIDENROTH, ANDREAS, LAMBERT, CAREY, CONNERTON, IAN, TWYCROSS, JAMIE, BAKER, MICHELLE, TYSON, JESS, KREFT, JAN-ULRICH and SOCKETT, R ELIZABETH, 2020. Journal of Bacteriology. 202(6), e00629-19
  • STOREY, D., MCNALLY, A., ASTRAND, M., SA-PESSOA GRACA SANTOS, J., RODRIGUEZ-ESCUDERO, I., ELMORE, B., PALACIOS, L., MARSHALL, H., HOBLEY, L., MOLINA, M., CID, V. J., SALMINEN, T. A. and BENGOECHEA, J. A., 2020. PLoS Pathog. 16(3), e1007969
  • SA-PESSOA, J., PRZYBYSZEWSKA, K., VASCONCELOS, F. N., DUMIGAN, A., FRANK, C. G., HOBLEY, L. and BENGOECHEA, J. A., 2020. MBio. 11(5),
  • HSU, C. Y., CAIRNS, L., HOBLEY, L., ABBOTT, J., O'BYRNE, C. and STANLEY-WALL, N. R., 2020. J Bacteriol. 202(7),
  • CADBY, IAN T., BASFORD, SARAH M., NOTTINGHAM, RUTH, MEEK, RICHARD, LOWRY, REBECCA, LAMBERT, CAREY, TRIDGETT, MATTHEW, TILL, ROB, AHMAD, RASHIDAH, FUNG, ROWENA, HOBLEY, LAURA, HUGHES, WILLIAM S., MOYNIHAN, PATRICK J., SOCKETT, R. ELIZABETH and LOVERING, ANDREW L., 2019. EMBO JOURNAL. 38(17),
  • AN, S. Q., DING, Y. C., FABER, F., HOBLEY, L. and SA-PESSOA, J., 2019. Microbiology (Reading). 165(2), 138-145
  • KIDD, TIMOTHY J., MILLS, GRANT, SA-PESSOA, JOANA, DUMIGAN, AMY, FRANK, CHRISTIAN G., INSUA, JOSE L., INGRAM, REBECCA, HOBLEY, LAURA and BENGOECHEA, JOSE A., 2017. EMBO MOLECULAR MEDICINE. 9(4), 430-447
  • MILLS, GRANT, DUMIGAN, AMY, KIDD, TIMOTHY, HOBLEY, LAURA and BENGOECHEA, JOSE A, 2017. Infection and immunity. 85(9),
  • HOBLEY, LAURA, LI, BIN, WOOD, JENNIFER L., KIM, SOK HO, NAIDOO, JACINTH, FERREIRA, ANA SOFIA, KHOMUTOV, MAXIM, KHOMUTOV, ALEXEY, STANLEY-WALL, NICOLA R. and MICHAEL, ANTHONY J., 2017. JOURNAL OF BIOLOGICAL CHEMISTRY. 292(29), 12041-12053
  • MORRIS, RYAN J., SCHOR, MARIEKE, GILLESPIE, RACHEL M. C., FERREIRA, ANA SOFIA, BALDAUF, LUCIA, EARL, CHRIS, OSTROWSKI, ADAM, HOBLEY, LAURA, BROMLEY, KEITH M., SUKHODUB, TETYANA, ARNAOUTELI, SOFIA, STANLEY-WALL, NICOLA R. and MACPHEE, CAIT E., 2017. SCIENTIFIC REPORTS. 7,
  • BROMLEY, K. M., MORRIS, R. J., HOBLEY, L., BRANDANI, G., GILLESPIE, R. M., MCCLUSKEY, M., ZACHARIAE, U., MARENDUZZO, D., STANLEY-WALL, N. R. and MACPHEE, C. E., 2015. Proc Natl Acad Sci U S A. 112(17), 5419-24
  • HOBLEY, L., HARKINS, C., MACPHEE, C. E. and STANLEY-WALL, N. R., 2015. FEMS Microbiol Rev. 39(5), 649-69
  • CAIRNS, L. S., HOBLEY, L. and STANLEY-WALL, N. R., 2014. Mol Microbiol. 93(4), 587-98
  • HOBLEY, L., KIM, S. H., MAEZATO, Y., WYLLIE, S., FAIRLAMB, A. H., STANLEY-WALL, N. R. and MICHAEL, A. J., 2014. Cell. 156(4), 844-54
  • MARLOW, V. L., PORTER, M., HOBLEY, L., KILEY, T. B., SWEDLOW, J. R., DAVIDSON, F. A. and STANLEY-WALL, N. R., 2014. J Bacteriol. 196(1), 16-27
  • CROSSMAN LC, CHEN H, CERDE脩O-T脕RRAGA A, BROOKS K, QUAIL MA, PINEIRO SA, HOBLEY L, SOCKETT RE, BENTLEY SD, PARKHILL J, WILLIAMS HN and STINE OC, 2013. The ISME journal. 7(1), 148-60
  • HOBLEY, L., OSTROWSKI, A., RAO, F. V., BROMLEY, K. M., PORTER, M., PRESCOTT, A. R., MACPHEE, C. E., VAN AALTEN, D. M. and STANLEY-WALL, N. R., 2013. Proc Natl Acad Sci U S A. 110(33), 13600-5
  • HOBLEY, L., FUNG, R.K.Y., LAMBERT, C., HARRIS, M.A.T.S., DABHI, J.M., KING, S.S., BASFORD, S.M., UCHIDA, K., TILL, R., AHMAD, R., AIZAWA, S., GOMELSKY, M. and SOCKETT, R.E., 2012. PLoS Pathogens. 8(2), e1002493
  • LAMBERT C, TILL R, HOBLEY L and SOCKETT RE, 2012. BMC microbiology. 12, 99
  • HOBLEY L, LERNER TR, WILLIAMS LE, LAMBERT C, TILL R, MILNER DS, BASFORD SM, CAPENESS MJ, FENTON AK, ATTERBURY RJ, HARRIS MATS and SOCKETT RE, 2012. BMC genomics. 13, 670
  • MOREHOUSE KA, HOBLEY L, CAPENESS M, SOCKETT RE., 2011. Journal of Bacteriology. 193(4), 932 - 943.
  • LAMBERT C, FENTON AK, HOBLEY L and SOCKETT RE, 2011. Journal of bacteriology. 193(12), 3139-41
  • LOVERING AL, CAPENESS MJ, LAMBERT C, HOBLEY L and SOCKETT RE, 2011. mBio. 2(5),
  • ATTERBURY, R.J., HOBLEY, L., TILL, R., LAMBERT, C., CAPENESS, M.J., LERNER, T.R., FENTON, A.K., BARROW, P. and SOCKETT, R.E., 2011. Applied and Environmental Microbiology. 77(16), 5794-803
  • CHANG C-Y., HOBLEY L., TILL R., CAPENESS M., KANNA M., BURTT W., JAGTAP P., AIZAWA S-I. and SOCKETT R.E., 2011. Microbiology. 157(11), 3079-3093
  • SHEN, F., HOBLEY, L., DOHERTY, N., LOH, J.T., COVER, T.L., SOCKETT, R.E., HARDIE, K.R. and ATHERTON, J.C., 2010. BMC Microbiology. 10, 210
  • FENTON, ANDREW K, HOBLEY, LAURA, BUTAN, CARMEN, SUBRAMANIAM, SRIRAM and SOCKETT, RENEE E, 2010. FEMS microbiology letters. 313, 89-95
  • LAMBERT C, HOBLEY L, CHANG C, FENTON A, CAPENESS M and SOCKETT L, 2009. Advances in microbial physiology. 54, 313-61
  • IIDA Y, HOBLEY L, LAMBERT C, FENTON AK, SOCKETT RE and AIZAWA S, 2009. Journal of molecular biology. 394(5), 1011-21
  • EVANS, K. J.; HOBLEY, L.; LAMBERT, C.; SOCKETT, R.E., 2007. Bdellovibrio - lone hunter "cousin" of the 鈥減ack hunting鈥� Myxobacteria. In: KAPLAN, H,; WHITWORTH, D., ed., Multicellularity and Differentiation Amongst the Myxobacteria and their Neighbours ASM Press.
  • HOBLEY, L., KING, J.R. and SOCKETT, R.E., 2006. Applied and Environmental Microbiology. 72(10), 6757-6765
  • LAMBERT, C, EVANS, KJ, TILL, R, HOBLEY, L, CAPENESS, M, RENDULIC, S, SCHUSTER, SC, AIZAWA, SI and SOCKETT, RE, 2006. Molecular Microbiology. 60(2), 274-286

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