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Contact

• workRoom C334 South Lab
  Sutton Bonington Campus
  Sutton Bonington
  Leicestershire
  LE12 5RD
  UK
• work01159516045
• fax0115 951 6099
• kamila.derecka@nottingham.ac.uk

Research Summary

My major research interests focus on molecular aspects of endocrinology, the biology of reproduction and fertility; especially the application of molecular biology methods for reproductive… read more

Recent Publications

• KATRIN M. SCHWARZ, ALEXANDER GROSSE-HONEBRINK, KAMILA DERECKA, CARLO ROTTA, YING ZHANG and NIGEL P. MINTON, 2017. Towards improved butanol production through targeted genetic modification of Clostridium pasteurianum Metabolic Engineering. (In Press.)
• DERECKA K, BLYTHE MJ, MALLA S, GENEREUX DP, GUFFANTI A, PAVAN P, MOLES A, SNART C, RYDER T, ORTORI CA, BARRETT DA, SCHUSTER E and STÖGER R, 2013. PLOS ONE. 8(7):e68191.,
• 1. DERECKA K, BALKWILL GD, GARNER TP, HODGMAN C, FLINT APF AND. SEARLE MS., 2010. Occurrence of a Quadruplex Motif in a Unique Insert within Exon C of the Bovine Estrogen Receptor α Gene (ESR1) Biochemistry. 49(35), 7625–7633
• BALKWILL,, DERECKA,, GARNER,, HODGMAN,, FLINT, and SEARLE,, 2009. Repression of translation of human estrogen receptor by G-quadruplex formation. Biochemistry.

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Current Research

My major research interests focus on molecular aspects of endocrinology, the biology of reproduction and fertility; especially the application of molecular biology methods for reproductive endocrinology.

Initially I studied LH receptor ontogeny in the porcine reproductive tract and oestrogen responsiveness in the reproductive system, at both molecular and cellular levels.

More recently I have concentrated on polymorphisms and gene expression in the context of reproduction and specially cattle infertility. Due to my particular interest in the endocrinology of reproduction, the main focus has been on gonadotrophin receptors, oestrogen receptors and cyclooxygenase-2, and its regulation by PPARs.

Selection of cows for milk yield during the last 5 decades has caused unfavourable changes in breeding values for fertility traits. This made the infertility in dairy cattle a growing problem. The single gene polymorphisms (SNPs) accumulated in genes involved in reproduction let us correlate the genetic make up of an individual animal to her performance, providing valuable information on the fertility of a sire's daughters.

 

• KATRIN M. SCHWARZ, ALEXANDER GROSSE-HONEBRINK, KAMILA DERECKA, CARLO ROTTA, YING ZHANG and NIGEL P. MINTON, 2017. Towards improved butanol production through targeted genetic modification of Clostridium pasteurianum Metabolic Engineering. (In Press.)
• DERECKA K, BLYTHE MJ, MALLA S, GENEREUX DP, GUFFANTI A, PAVAN P, MOLES A, SNART C, RYDER T, ORTORI CA, BARRETT DA, SCHUSTER E and STÖGER R, 2013. PLOS ONE. 8(7):e68191.,
• 1. DERECKA K, BALKWILL GD, GARNER TP, HODGMAN C, FLINT APF AND. SEARLE MS., 2010. Occurrence of a Quadruplex Motif in a Unique Insert within Exon C of the Bovine Estrogen Receptor α Gene (ESR1) Biochemistry. 49(35), 7625–7633
• BALKWILL,, DERECKA,, GARNER,, HODGMAN,, FLINT, and SEARLE,, 2009. Repression of translation of human estrogen receptor by G-quadruplex formation. Biochemistry.
• K. DERECKA, S. AHMAD, T. C. HODGMAN, N. HASTINGS, M. D. ROYAL, J. A. WOOLLIAMS, A. P. F. FLINT, 2009. Sequence variants in the bovine gonadotrophin releasing hormone receptor gene and their associations with fertility (p) Animal Genetics. (In Press.)
• SHELDRICK ELR , DERECKA K, MARSHALL E, CHIN EC, HODGES L, WATHES DC, ABAYASEKARA DRE, FLINT APF, 2007. Peroxisome proliferator-activated receptors and the control of levels of prostaglandin-endoperoxide synthase 2 by arachidonic acid in the bovine uterus Biochemical Journal. 406, 175-183.
• DERECKA, K, WANG, C K and FLINT, A P F, 2006. Interactions between the cytomegalovirus promoter and the estrogen response element: implications for design of estrogen-responsive reporter plasmids. Journal of Biomolecular Techniques. 17(3), 218-227
• HASTINGS, N, DONN, S, DERECKA, K, FLINT, A P and WOOLLIAMS, J A, 2006. Animal Genetics. 37(6), 583-5
• DERECKA,K., HUNTER,M., ROYAL,M.D., SMITH,C. and FLINT, A.P.F, 2004. Journal of Genome Science and Technology. 3(1), 15-17
• LEUNG, S.T., CHENG, Z., SHELDRICK, E.L., DERECKA, K., FLINT, A.P.F. and WATHES, D.C., 2001. Journal of Endocrinology. VOL 168(PART 3), 497-508
• DEMMERS, K J, DERECKA, K and FLINT, A, 2001. Reproduction. 121(1), 41-9
• ZIECIK, A. J., DERECKA, K., GOWRONSKA, B., STEPIEN, A. and BODEK, G., 2001. SEMINARS IN REPRODUCTIVE MEDICINE. VOL 19(PART 1), 19-30
• LEUNG, S T, DERECKA, K, MANN, G E, FLINT, A P and WATHES, D C, 2000. Journal of Reproduction and Fertility. 119(1), 25-33
• STEPIEN, A, DERECKA, K, GAWRONSKA, B, BODEK, G, ZWIERZCHOWSKI, L, SHEMESH, M and ZIECIK, A J, 2000. LH/hCG receptors in the porcine uterus--a new evidence of their presence in the cervix. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.. 51(4 Pt 2), 917-31
• KAMIÅ„SKI, T, GAWROÅ„SKA, B, DERECKA, K, OKRASA, S and PRZAÅ‚A, J, 2000. Gene expression and peptide localization for LH/hCG receptor in porcine small and large luteal cells: possible regulation by opioid peptides. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.. 51(2), 359-68
• DERECKA, K, ZHANG, F P, ZIECIK, A J and HUHTANIEMI, I, 1999. Ontogeny of LH receptor gene expression in the pig reproductive tract. Journal of Reproduction and Fertility. 115(2), 365-72
• WASOWICZ, G, DERECKA, K, STEPIEN, A, PELLINIEMI, L, DOBOSZYNSKA, T, GAWRONSKA, B and ZIECIK, A J, 1999. Evidence for the presence of luteinizing hormone-chorionic gonadotrophin receptors in the pig umbilical cord. Journal of Reproduction and Fertility. 117(1), 1-9
• FLINT, A, KALUZ, S, KALUZOVA, M, SHELDRICK, L, FISHER, P and DERECKA, K, 1999. BioTechniques. 27(4), 728-32
• DERECKA, K and ZIECIK, A J, 1997. Theriogenology. 48(1), 51-62
• DERECKA, K, PIETILä, E M, RAJANIEMI, H J and ZIECIK, A J, 1995. Cycle dependent LH/hCG receptor gene expression in porcine nongonadal reproductive tissues. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.. 46(1), 77-85
• DERECKA, KAMILA, BLYTHE, MARTIN J, MALLA, SUNIR, GENEREUX, DIANE P, GUFFANTI, ALESSANDRO, PAVAN, PAOLO, MOLES, ANNA, SNART, CHARLES, RYDER, THOMAS, ORTORI, CATHARINE A, BARRETT, DAVID A, SCHUSTER, EUGENE and STOGER, REINHARD, PloS one. 8(7), e68191