糖心原创

Contact

• workRoom B206 South Building
  Sutton Bonington Campus
  Sutton Bonington
  Leicestershire
  LE12 5RD
  UK
• Masaki.Kinoshita@nottingham.ac.uk

Research Summary

Pluripotency in mammalian embryos and in culture

My research interest is pluripotent cell state in early embryos and captured ones in vitro. Pluripotency exists in early mammalian embryos but transiently. This period is further dissected into three consecutive phases termed, "naive", "formative" and "primed". These three phases are continuum but functionally distinct. We want to understand how cells transit through these phases, how they are captured molecularly and what kinds of gene regulatory network and epigenetic modification provide the functional differences. We will address the mechanisms of pluripotency and stem cell culture including mouse, livestock and human.

Recent Publications

• KINOSHITA, M., BARBER, M., MANSFIELD, W., CUI, Y., SPINDLOW, D., STIRPARO, G. G., DIETMANN, S., NICHOLS, J. and SMITH, A., 2021. Cell stem cell. 28(3), 453-471 e8
• KINOSHITA, MASAKI, KOBAYASHI, TOSHIHIRO, PLANELLS, BENJAMIN, KLISCH, DORIS, SPINDLOW, DANIEL, MASAKI, HIDEKI, BORNEL脰V, SUSANNE, STIRPARO, GIULIANO GIUSEPPE, MATSUNARI, HITOMI, UCHIKURA, AYUKO, LAMAS-TORANZO, ISMAEL, NICHOLS, JENNIFER, NAKAUCHI, HIROMITSU, NAGASHIMA, HIROSHI, ALBERIO, RAMIRO and SMITH, AUSTIN, 2021. Development. 148(23),
• KINOSHITA, M., LI, M. A., BARBER, M., MANSFIELD, W., DIETMANN, S. and SMITH, A., 2021. Proceedings of the National Academy of Sciences of the United States of America. 118(38),
• BURGOLD, T., BARBER, M., KLOET, S., CRAMARD, J., GHARBI, S., FLOYD, R., KINOSHITA, M., RALSER, M., VERMEULEN, M., REYNOLDS, N., DIETMANN, S. and HENDRICH, B., 2019. The EMBO journal.

• View all publications

• KINOSHITA, M., BARBER, M., MANSFIELD, W., CUI, Y., SPINDLOW, D., STIRPARO, G. G., DIETMANN, S., NICHOLS, J. and SMITH, A., 2021. Cell stem cell. 28(3), 453-471 e8
• KINOSHITA, MASAKI, KOBAYASHI, TOSHIHIRO, PLANELLS, BENJAMIN, KLISCH, DORIS, SPINDLOW, DANIEL, MASAKI, HIDEKI, BORNEL脰V, SUSANNE, STIRPARO, GIULIANO GIUSEPPE, MATSUNARI, HITOMI, UCHIKURA, AYUKO, LAMAS-TORANZO, ISMAEL, NICHOLS, JENNIFER, NAKAUCHI, HIROMITSU, NAGASHIMA, HIROSHI, ALBERIO, RAMIRO and SMITH, AUSTIN, 2021. Development. 148(23),
• KINOSHITA, M., LI, M. A., BARBER, M., MANSFIELD, W., DIETMANN, S. and SMITH, A., 2021. Proceedings of the National Academy of Sciences of the United States of America. 118(38),
• BURGOLD, T., BARBER, M., KLOET, S., CRAMARD, J., GHARBI, S., FLOYD, R., KINOSHITA, M., RALSER, M., VERMEULEN, M., REYNOLDS, N., DIETMANN, S. and HENDRICH, B., 2019. The EMBO journal.
• STUART, H. T., STIRPARO, G. G., LOHOFF, T., BATES, L. E., KINOSHITA, M., LIM, C. Y., SOUSA, E. J., MASKALENKA, K., RADZISHEUSKAYA, A., MALCOLM, A. A., ALVES, M. R. P., LLOYD, R. L., NESTOROWA, S., HUMPHREYS, P., MANSFIELD, W., REIK, W., BERTONE, P., NICHOLS, J., GOTTGENS, B. and SILVA, J. C. R., 2019. Cell stem cell. 25(3), 388-406 e8
• KINOSHITA, MASAKI and SMITH, AUSTIN, 2018. Dev Growth Differ.
• LI, M. A., AMARAL, P. P., CHEUNG, P., BERGMANN, J. H., KINOSHITA, M., KALKAN, T., RALSER, M., ROBSON, S., VON MEYENN, F., PARAMOR, M., YANG, F., CHEN, C., NICHOLS, J., SPECTOR, D. L., KOUZARIDES, T., HE, L. and SMITH, A., 2017. Elife. 6,
• KINOSHITA, M., 2015. Reprod Med Biol. 14(3), 85-98
• KINOSHITA, M., SHIMOSATO, D., YAMANE, M. and NIWA, H., 2015. BMC developmental biology. 15(1), 37
• KINOSHITA, M., ERA, T., JAKT, L. M. and NISHIKAWA, S., 2009. Development. 136(12), 2069-79
• TADA, S., ERA, T., FURUSAWA, C., SAKURAI, H., NISHIKAWA, S., KINOSHITA, M., NAKAO, K. and CHIBA, T., 2005. Development. 132(19), 4363-74